Hyperpolarized 129Xe Diffusion MRI and Diffusion Morphometry in Mice using 2D Spiral
Mariah L. Costa1,2, Brice J. Albert1, Abdullah S. Bdaiwi1,2, Harshavardhana H. Ediga3,4, Satish K. Madala3,5, Peter J. Niedbalski1,6, and Zackary I. Cleveland1,2,3,5,7
1Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, 3Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 4Biochemistry, National Institute of Nutrition, Telangana, India, 5Pediatrics, University of Cincinnati, Cincinnati, OH, United States, 6Pulmonary and Critical Care, University of Kansas Medical Center, Kansas City, KS, United States, 7Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States
Hyperpolarized (HP) 129Xe diffusion imaging, including the apparent diffusion coefficient (ADC) and more sophisticated diffusion morphometry, can assess microstructural dimensions of the acinar airspace. In diseases characterized by alveolar destruction (eg, emphysema), these parameters strongly indicate disease severity. Here, a time-efficient, 2D-spiral diffusion sequence was developed and compared to a conventional GRE-based sequence in a free-diffusion phantom, wild-type mice, a and a transgenic mouse model of lung fibrosis that develops emphysema as a comorbidity. Both sequences provided comparable SNR, ADC values, and morphometry metrics, indicating spiral sequences can assess airspace size in mice, while making efficient use of HP magnetization.
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