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Abstract #1177

Intra-Visit and Inter-Visit Repeatability of 129Xe Multiple-Breath Washout MRI in Children with Stable Cystic Fibrosis Lung Disease

Faiyza Shoaib Alam1,2, Brandon Zanette2, Sharon Braganza2, Daniel Li2, Felix Ratjen2,3, and Giles Santyr1,2
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, 3Division of Respirology, Hospital for Sick Children, Toronto, ON, Canada


Hyperpolarized 129Xe MRI (Xe-MRI) yielding VDP has shown advantages over conventional PFT’s for assessing paediatric CF lung disease but is only a static “snapshot” of a dynamic process. Xe-MRI can be conducted in a MBW fashion to yield temporal/spatial heterogeneity of the gas during respiration, resulting in regional maps of fractional ventilation (r), a measure of percent gas clearance per breath. This work assessed the within-visit and inter-visit repeatability of MBW Xe-MRI between baseline and one-month follow-up in paediatric subjects with stable CF and found strong intra- and inter-visit repeatability. Significant correlations between MBW Xe-MRI and LCI were also found.

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