Abstract #1189

Hyperpolarized [1-13C]Pyruvate MRI of Spleen: Monitoring Immune Activation for Cervical Cancer Patient following Radiotherapy

Gigin Lin¹, Ying-Chieh Lai¹, Kuan-Ying Lu¹, Albert P Chen², and Ching-Yi Hsieh³

¹Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taiwan, ²GE Healthcare, Toronto, ON, Canada, ³Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University, Taoyuan, Taiwan

Synopsis

Successful cancer therapy depends on an optimal immune response, but noninvasive tools are lacking to monitor this dynamic process. In this proof-of-concept human study, we demonstrated hyperpolarized [1-13C]pyruvate MRI of the spleen monitoring the immune activation for cancer patients at the early time point following radiotherapy, by measuring the pyruvate-to-lactate conversion rate. The ADC-based cellularity of the spleen, however, did not detect remarkable changes.

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