Meeting Banner
Abstract #1189

Hyperpolarized [1-13C]Pyruvate MRI of Spleen: Monitoring Immune Activation for Cervical Cancer Patient following Radiotherapy

Gigin Lin1, Ying-Chieh Lai1, Kuan-Ying Lu1, Albert P Chen2, and Ching-Yi Hsieh3
1Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taiwan, 2GE Healthcare, Toronto, ON, Canada, 3Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University, Taoyuan, Taiwan


Successful cancer therapy depends on an optimal immune response, but noninvasive tools are lacking to monitor this dynamic process. In this proof-of-concept human study, we demonstrated hyperpolarized [1-13C]pyruvate MRI of the spleen monitoring the immune activation for cancer patients at the early time point following radiotherapy, by measuring the pyruvate-to-lactate conversion rate. The ADC-based cellularity of the spleen, however, did not detect remarkable changes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here