Towards 15N molecular MRI with 15N-nicotinamide hyperpolarized by dissolution dynamic nuclear polarization (dDNP)
Josh Peters1, Arne Brahms2, Vivian Janicaud1,3, Mariia Anikeeva1, Eva Peschke1, Frowin Ellermann1, Arianna Ferrari1, Konrad Aden4, Stefan Schreiber4, Rainer Herges2, Jan-Bernd Hövener1, and Andrey N. Pravdivtsev1
1SBMI, MOIN CC, UKSH, Kiel University, Kiel, Germany, 2Otto Diels Institute for Organic Chemistry, Kiel University, Kiel, Germany, 3Universität zu Lübeck, Lübeck, Germany, 4Institute of Clinical Molecular Biology, UKSH, Kiel University, Kiel, Germany
We synthesized 1-15N nicotinamide (NA) and built a saddle-shaped mouse body linear coil for 15N imaging. We found a way to polarize 1-15N-NA by dissolution dynamic nuclear polarization to 9.1±4.4% and measured the effect of the radical load. The lifetime of hyperpolarized NA was field-dependent: 100 s at 1 T, 60 s at 7 T, and 30 s at 9.4 T. An effect of the pH on liquid-state polarization was found. N FLASH MRI of hyperpolarized NA was acquired in less than 1 s.
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