Our understanding of the CSF exchange with surrounding tissues and its correlation with brain function is limited. We presented the first non-invasive MRI methods to quantify this process with two novel T1 and ADC Phase Alternate LAbeling with Null recovery (PALAN) schemes. The CSF signal was nulled, while the partial recovery of other tissues was labeled by alternating the phase of the pulse by using the significantly different T1 and ADC values between CSF and the other tissues. Rapid and major CSF water exchange occurs on the surface of the ventricles.
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