Abstract #1206

Caffeine acutely reduces aqueductal CSF flow in humans

Tekla Maria Kylkilahti^1,2, Max Wictor^1,2, Johannes Töger³, Karin Markenroth Bloch ^4,5, and Iben Lundgaard^1,2

¹1Department of Experimental Medical Science, Lund University, Lund, Sweden, ²Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden, ³Department of Clinical Sciences, Diagnostic Radiology, Lund University, Skåne University Hospital, Lund, Sweden, ⁴Department of Medical Radiation Physics, Lund University, Lund, Sweden, ⁵Lund University Bioimaging Center, Lund University, Lund, Sweden

Synopsis

In this ultra-high field 7T MRI study, we find that caffeine acutely reduces CSF net flow in humans. Interestingly, regular caffeine consumption seems to be protective against this reduction. We used non-invasive 2D PC 7T MRI in healthy volunteers to measure CSF flow in the cerebral aqueduct. Ventricular CSF flow is upstream of the glymphatic system and may thus reflect or affect the function of CSF-mediated clearance pathways that have been suggested to be important for waste product removal in the brain. Better understanding of CSF dynamics may help us find new targets for treating proteinopathies such as Alzheimer’s disease.

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