Abstract #1207

Assessment of Choroid Plexus Perfusion and the Blood-CSF Barrier with Multi Post Label Delay Arterial Spin Labeling MRI and Vasodilation

Yufei David Zhu¹, Moss Zhao², Bin Shen², Greg Zaharchuk², and Audrey Peiwen Fan^1,3

¹Biomedical Engineering, University of California, Davis, Davis, CA, United States, ²Radiology, Stanford University, Palo Alto, CA, United States, ³Neurology, University of California, Davis, Davis, CA, United States

Synopsis

The choroid plexus contributes to the production of cerebrospinal fluid (CSF), maintains electrolyte and metabolic balance, and plays important immunological roles. Here, we sought to determine whether multi-post label delay (PLD) arterial spin labeling (ASL) MRI could robustly measure cerebral blood flow (CBF) in the choroid plexus and its response to a vasodilatory challenge. We saw choroid plexus perfusion increase by 30 ml/100g/min (p=0.0003) with acetazolamide. We also calculated the ratio of the choroid plexus to anterior ventricle ASL signal (rCV) as a clinically useful biomarker of blood-CSF passage and observed an average increase of 0.529 in rCV post vasodilation.

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