Glymphatic clearance has been associated with an increase in interstitial volume fraction during sleep. Higher order diffusion weighted MRI images were acquired of awake and sleeping participants to investigate glymphatic system related changes. Sleep was associated with a significant decrease in kurtosis measures. Clusters with significant decrease in radial kurtosis were located in default mode network areas, occipital cortex, thalamus, midbrain and temporal lobe. Decrease in kurtosis is in line with the glymphatic system hypothesis, as diffusion becomes more Gaussian when it is less restricted, which expected with the increase in interstitial space volume.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords