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Abstract #1209

Using diffusion kurtosis imaging to measure glymphatic system related changes during human sleep

Balázs Örzsik1, Mara Cercignani2, and Neil Harrison2
1BSMS, University of Sussex, Brighton, United Kingdom, 2Cardiff University, Cardiff, United Kingdom


Glymphatic clearance has been associated with an increase in interstitial volume fraction during sleep. Higher order diffusion weighted MRI images were acquired of awake and sleeping participants to investigate glymphatic system related changes. Sleep was associated with a significant decrease in kurtosis measures. Clusters with significant decrease in radial kurtosis were located in default mode network areas, occipital cortex, thalamus, midbrain and temporal lobe. Decrease in kurtosis is in line with the glymphatic system hypothesis, as diffusion becomes more Gaussian when it is less restricted, which expected with the increase in interstitial space volume.

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