Glymphatic clearance has been associated with an increase in interstitial volume fraction during sleep. Higher order diffusion weighted MRI images were acquired of awake and sleeping participants to investigate glymphatic system related changes. Sleep was associated with a significant decrease in kurtosis measures. Clusters with significant decrease in radial kurtosis were located in default mode network areas, occipital cortex, thalamus, midbrain and temporal lobe. Decrease in kurtosis is in line with the glymphatic system hypothesis, as diffusion becomes more Gaussian when it is less restricted, which expected with the increase in interstitial space volume.
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