Abstract #1210

Detection of enhanced cerebrospinal fluid transport during dexmedetomidine anesthesia in the rat using diffusion, T2 and morphometric MRI

Elizabeth B Hutchinson¹, Anakaren Romero-Lozano¹, Jean-Pierre Galons¹, Christine Howison¹, Alexandru Avram², Nathan Williamson², Michal Komlosh², and Peter J Basser²

¹Biomedical Engineering, University of Arizona, Tucson, AZ, United States, ²NICHD/NIH, Bethesda, MD, United States

Synopsis

The enhancement of CSF transport in a robust experimental model was measurable using in-vivo quantitative MRI.TBM and voxelwise T2 mapping analysis were both able to changes in regions that are known to be associated with CSF transport based on contrast-enhancement studies. These two methods do not require contrast and if validated could provide a non-contrast outcome metric for health of the CSF transport system. Diffusion MRI outcomes suggest that it may be possible to sensitize the diffusion MRI paradigm to CSF transport and this is an area for future research.

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