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Abstract #1211

In vivo CSF Flow During Central Sensitization Using Fourier Velocity Encoded MRI at 21.1 T

Dayna L. Richter1,2, Samuel W. Holder1,2, and Samuel C. Grant1,2
1National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States

Synopsis

Cerebrospinal fluid (CSF) flow was evaluated temporally in a preclinical migraine model at 21.1 T. As elevated sodium levels are implicated in the progression of migraine, evaluating how sodium is transported in the ventricular system and brain should provide insight on bulk sodium accumulation around, among and within anatomical regions implicated in migraine. A series of Fourier Velocity Encoding MRI was acquired over 2 h post-nitroglycerin injection to evaluate CSF flow during the progression of central sensitization.

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