Sleep and waste clearance: The association of sleep quality with a 7T IVIM imaging derived proxy of interstitial fluid
Merel M. van der Thiel1,2, Gerhard S. Drenthen1,2, Paulien H.M. Voorter1,2, Thorsten Feiweier3, Inez H.G.B. Ramakers2,4, Walter H. Backes1,2,5, and Jacobus F.A. Jansen1,2,6
1Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 2School for Mental Health & Neuroscience, Maastricht University, Maastricht, Netherlands, 3Siemens Healthcare, Erlangen, Germany, 4Department of Psychiatry & Neuropsychology, Maastricht University, Maastricht, Netherlands, 5School for Cardiovascular Disease, Maastricht University, Maastricht, Netherlands, 6Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
Cerebral clearance is most active during sleep, therefore reduced sleep quality might induce impaired clearance function. Interstitial fluid (ISF) washes waste products from in-between cells through the parenchyma and its volume is found to be regulated by the sleep-wake cycle. Assessment of the ISF-fraction through IVIM can be a potential, non-invasive method to determine sleep-related variations in ISF, without contamination of parenchymal or microvascular diffusion. The current exploratory study investigates the potential of the IVIM-derived ISF-fraction to assess ISF-volume changes in relation to sleep by examining whether these changes are driven by actual hours of sleep or self-reported sleep quality.
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