Neurodegenerative diseases are thought to involve changes in the cerebrospinal fluid (CSF). Since glaucoma is a neurodegenerative disease of the visual system, here, we examined the CSF dynamics in glaucoma patients. Specifically, using resting-state fMRI, we observed that early glaucoma patients present greater power in the low frequency of the CSF flow and greater coupling between CSF flow and global brain activity compared to late glaucoma patients. Further, the coupling between CSF flow and global brain activity is associated with the volumes of the optic nerve and optic chiasm. Overall, our results suggest that glaucoma involves changes in CSF flow.
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