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Abstract #1215

Altered neurovascular coupling in patients with MELAS evaluated by combining cerebral blood flow and regional homogeneity

Rong Wang1, Yuxin Li1, Jie Lin1, and Yong Zhang2
1Huashan Hospital, Shanghai, China, 2GE Healthcare, Shanghai, China, Shanghai, China


This is the first study that used a combined arterial spin labeling (ASL) and resting-state fMRI approach to assess the neurovascular coupling in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), which may provide a new mechanistic perspective into understanding numerous brain diseases.

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