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Abstract #1216

Non-invasive assessment of blood-brain barrier permeability in multiple sclerosis patients by arterial spin labeling.

Andre Monteiro Paschoal1, Mateus Boaventura1, Leonie Petitclerc2, Matthias J.P. van Osch2, Maria Concepcion Garcia Otaduy1, Samira Luisa Apostolos-Pereira3, Dagoberto Callegaro3, and Carolina de Medeiros Rimkus1
1Institute of Radiology and Department of Radiology and Oncology, University of Sao Paulo, Sao Paulo, Brazil, 2C.J. Gorter Center for high field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Departamento de Neurologia, Hospital das Clinicas da Faculdade de Medicina, University of Sao Paulo, Sao Paulo, Brazil


Multiple sclerosis is a demyelinating disease affecting the central nervous system. Although MS lesions can be identified by conventional MRI, the evaluation of active lesions in normal appearing gray and white matter requires measures of blood-brain barrier permeability (BBB), which is commonly assessed through the dynamic contrast enhanced (DCE) acquisition. When repeated scans are needed in the MS patients follow-up, repeated gadolinium injection is not recommended. This study successfully showed the feasibility of advanced arterial spin labeling sequences as an alternative to evaluate BBB permeability, whose results of water-exchange times across the BBB were in agreement with DCE measurements.

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