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Abstract #1217

Implementation of non-invasive Filter-Exchange Imaging (FEXI) to measure blood-brain barrier water exchange in the rat brain

Yolanda Ohene1,2, Elizabeth Powell3,4, Samo Lasič5,6, Geoff J. M Parker3,7,8, Laura M Parkes 1,2, and Ben R Dickie 2,9
1Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, 2Geoffrey Jefferson Brain Research Centre, University of Manchester, Manchester, United Kingdom, 3Centre for Medical Image Computing, UCL, London, United Kingdom, 4Department of Computer Science, UCL, London, United Kingdom, 5Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Amager and Hvidovre, Copenhagen, Denmark, 6Random Walk Imaging, Lund, Sweden, 7Department of Medical Physics and Biomedical Engineering, UCL, London, United Kingdom, 8Bioxydyn Limited, Manchester, United Kingdom, 9Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, United Kingdom


We have developed a preclinical FEXI sequence optimised to measure water exchange across the blood-brain barrier in the rat brain. Simulated synthetic data estimated an apparent exchange rate (AXR) of 1.22 s-1, using the in-vivo acquisition parameters and exchange rate constant = 2.5 s-1, reflecting in-vivo measurements. The experimental normalised AXR in the rat brain was measured at 3.34 ± 1.14 s-1 (scan) and 3.62 ± 0.96 s-1 (rescan), with CoV = 26%, n = 10. This technique is a promising non-invasive tool which can be applied to in a wide range of disease models, including neurodegeneration, stroke and neuroinflammation.

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