We have developed a preclinical FEXI sequence optimised to measure water exchange across the blood-brain barrier in the rat brain. Simulated synthetic data estimated an apparent exchange rate (AXR) of 1.22 s-1, using the in-vivo acquisition parameters and exchange rate constant = 2.5 s-1, reflecting in-vivo measurements. The experimental normalised AXR in the rat brain was measured at 3.34 ± 1.14 s-1 (scan) and 3.62 ± 0.96 s-1 (rescan), with CoV = 26%, n = 10. This technique is a promising non-invasive tool which can be applied to in a wide range of disease models, including neurodegeneration, stroke and neuroinflammation.
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