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Abstract #1224

Quantitative functional brain mapping imaging using Arterial Spin Labelling for safe neurosurgery

Giannina Rita Iannotti1,2, Isaure Nadin1, Quentin Tourdot3, Shahan Momjian1, Karl Schaller1, Karl Lovblad2, and Frédéric Grouiller4,5
1Department of Neurosurgery, University Hospital of Geneva, Geneva, Switzerland, 2Department of Radiology and Medical Informatics, University Hospital of Geneva, Geneva, Switzerland, 3Faculty of Pharmacy, University of Montpellier, France, Montpellier, France, 4Laboratory of Behavioral Neurology and Imaging of Cognition, Department of Fundamental Neuroscience, University of Geneva, Geneva, Switzerland, 5Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland


Brain functional mapping is fundamental in pre-surgical workflow to target areas to be preserved. This work aims at validating ASL as alternative to BOLD to map eloquent cortex, by offering a quantitative measure of the perfusion associated to neuronal activity. Thirty healthy subjects underwent TMS motor mapping and executed a clenching-motor-task in a 3T-MR-scanner, while ASL and BOLD volumes were acquired simultaneously. The comparison between the global maxima of BOLD and ASL activations revealed that ASL localizes significantly deeper and more anteriorly than BOLD. ASL global maximum was found closer than BOLD to the most representative point of TMS mapping.

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