Abstract #1224

Quantitative functional brain mapping imaging using Arterial Spin Labelling for safe neurosurgery

Giannina Rita Iannotti^1,2, Isaure Nadin¹, Quentin Tourdot³, Shahan Momjian¹, Karl Schaller¹, Karl Lovblad², and Frédéric Grouiller^4,5

¹Department of Neurosurgery, University Hospital of Geneva, Geneva, Switzerland, ²Department of Radiology and Medical Informatics, University Hospital of Geneva, Geneva, Switzerland, ³Faculty of Pharmacy, University of Montpellier, France, Montpellier, France, ⁴Laboratory of Behavioral Neurology and Imaging of Cognition, Department of Fundamental Neuroscience, University of Geneva, Geneva, Switzerland, ⁵Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland

Synopsis

Brain functional mapping is fundamental in pre-surgical workflow to target areas to be preserved. This work aims at validating ASL as alternative to BOLD to map eloquent cortex, by offering a quantitative measure of the perfusion associated to neuronal activity. Thirty healthy subjects underwent TMS motor mapping and executed a clenching-motor-task in a 3T-MR-scanner, while ASL and BOLD volumes were acquired simultaneously. The comparison between the global maxima of BOLD and ASL activations revealed that ASL localizes significantly deeper and more anteriorly than BOLD. ASL global maximum was found closer than BOLD to the most representative point of TMS mapping.

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