Abstract #1225

Shear-rate values in the carotid bifurcation in subjects with carotid webs, subjects with atherosclerotic lesions, and healthy subjects.

Retta El Sayed^1,2, Alireza Sharifi², Charlie Park², Diogo Haussen³, Jason Allen^1,2,3, and John N Oshinski^1,2

¹Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, United States, ²Department of Radiology & Imaging Sciences, Emory University, Atlanta, GA, United States, ³Department of Neurology, Emory University, Atlanta, GA, United States

Synopsis

Carotid webs (CaWs) have been linked to cryptogenic strokes and therefore quantifying different hemodynamic parameters is essential to understand the mechanism of clot formation in patients. Computational fluid dynamics (CFD) based on patient-specific geometry and PCMR inlet flow conditions was conducted on five subjects with CaWs, five subjects with mild atherosclerosis (with a similar degree of luminal narrowing), and three healthy control subjects. The total area within the carotid bifurcation that contained low shear rate values associated with clot formation is significantly larger in CaW subjects compared to subjects with atherosclerotic lesions or healthy subjects.

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