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Abstract #1226

Repeatability and reliability of 2D phase-contrast and 4D flow MRI when measuring cerebral arterial and venous pulsatility

Alasdair Graeme Morgan1, Michael Graeme Thrippleton1, Ning Jin2, Joanna Wardlaw1, and Ian Marshall1
1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 2Siemens Medical Solutions USA, Inc., Cleveland, OH, United States


We examined the test-retest repeatability and intraobserver reliability of 4D flow MRI while assessing the pulsatility and flow rates of a variety of cerebral arteries and veins in healthy volunteers. A subset of these vessels were also measured using 2D phase-contrast MRI, a more established method, to assess the level to which the lower-resolution (but higher-coverage) 4D method could compare to its 2D counterpart. Flow pulsatility appears to play a role in the development of cerebral small vessel disease and so testing the capabilities of 4D flow in this context is an important step before applying it to clinical studies.

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