IVIM Diffusion-Weighted MRI in Detecting Graft Function with Complications Immediately After Kidney Transplantations
JyhWen Chai1,2, Yung-Chien Chang1,3, Kuan-Jung Pan4, Mu-Chih Chung5, Hsian-Min Chen4, and Feng-Mao Chiu6
1Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, 2College of Medicine, National Chung Hsin University, Taichung, Taiwan, 3Department of Electrical Engineering, National Chung Hsin University, Taichung, Taiwan, 4Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, 5Section of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan, 6Department of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan
Delayed graft function (DGF) is a form of acute renal failure that results in post-transplantation oliguria, with various frequencies from 2% to 50%. Heretofore, there was a lack of imaging biomarkers to interpolate the DGF. The tri-exponential intravoxel incoherent motion (IVIM) model, providing three distinct signal fractions of a pure diffusion, an intermediate and an ultrafast component, is more preferable for the diffusion signal in the allograft kidneys than the mono- and bi-exponential models. Our experiment illustrates that tri-exponential IVIM model could provide a good indicator for distinguishing the early graft function, the delayed graft function without and with complications.
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