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Abstract #1236

Neonatal seizures induce significant changes in cerebral oxidative metabolism

Agnieszka Sierhej1, Alan Bainbridge2, Giles Kendall3, Magdalena Sokolska2, Kelly Pegoretti-Baruteau3, Janet Rennie3, Sean R Mathieson4, Nicola J Robertson5, Geraldine Boylan4, and Subhabrata Mitra5
1University College London, London, United Kingdom, 2Medical Physics and Bioengineering, University College London Hospitals, London, United Kingdom, 3Neonatal Unit, University College London Hospitals, London, United Kingdom, 4INFANT Research Centre, University College Cork, Cork, Ireland, 5Institute for Women's Health, University College London, London, United Kingdom


Neonatal seizures are common following neonatal encephalopathy and have the potential for themselves to cause further brain injury. Data were collected from 55 term neonates who underwent therapeutic hypothermia following neonatal encephalopathy. 25 developed seizures. Magnetic resonance Spectroscopy showed that in the seizure group, lactate was increased and Naa and Choline were decreased. Lower tNaa in neonates with seizures likely indicates further neuronal injury and may explain seizure induced neurological deficits

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