Abstract #1236

Neonatal seizures induce significant changes in cerebral oxidative metabolism

Agnieszka Sierhej¹, Alan Bainbridge², Giles Kendall³, Magdalena Sokolska², Kelly Pegoretti-Baruteau³, Janet Rennie³, Sean R Mathieson⁴, Nicola J Robertson⁵, Geraldine Boylan⁴, and Subhabrata Mitra⁵

¹University College London, London, United Kingdom, ²Medical Physics and Bioengineering, University College London Hospitals, London, United Kingdom, ³Neonatal Unit, University College London Hospitals, London, United Kingdom, ⁴INFANT Research Centre, University College Cork, Cork, Ireland, ⁵Institute for Women's Health, University College London, London, United Kingdom

Synopsis

Neonatal seizures are common following neonatal encephalopathy and have the potential for themselves to cause further brain injury. Data were collected from 55 term neonates who underwent therapeutic hypothermia following neonatal encephalopathy. 25 developed seizures. Magnetic resonance Spectroscopy showed that in the seizure group, lactate was increased and Naa and Choline were decreased. Lower tNaa in neonates with seizures likely indicates further neuronal injury and may explain seizure induced neurological deficits

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