Abstract #1237
Reduced neonatal fronto-limbic connectivity is associated with higher externalizing symptoms in toddlers with Congenital Heart Disease
Alexandra F Bonthrone1, Andrew Chew1, Megan Ní Bhroin1,2, Christopher J Kelly1, Daan Christiaens1,3, Maximilian Pietsch1,4, J-Donald Tournier1, Lucilio Cordero-Grande1,5, Joseph V Hajnal1,6, Kuberan Pushparajah6,7, John Simpson7, A David Edwards1, Mary A Rutherford1, Chiara Nosarti1,8, Dafnis Batalle1,4, and Serena J Counsell1
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Trinity College Institute of Neuroscience and Cognitive Systems Group, Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland, 3Department of Electrical Engineering (ESAT/PSI), KU Leuven, Leuven, Belgium, 4Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, 5Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid & CIBER-BBN, Madrid, Spain, 6Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 7Paediatric Cardiology Department, Evelina London Children's Healthcare, London, United Kingdom, 8Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
Synopsis
Infants with Congenital Heart Disease (CHD) are at increased risk of neurodevelopmental impairments. Forty-three neonates with CHD underwent multi-shell high angular resolution diffusion MRI (HARDI) on a 3T scanner before surgery. At 22 months parents completed a questionnaire characterising internalizing and externalizing behaviours. Network-based statistics were used to characterise the relationship between internalizing and externalizing symptoms and structural connectivity. Reduced neonatal structural connectivity in fronto-limbic regions before surgery was associated with increased externalizing symptomatology in toddlers with CHD.
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