MRI assessment of cerebral oxygen delivery before and after surgery in infants with congenital heart disease
Daniel Cromb1,2, Alexandra F Bonthrone1, Christopher Kelly1, Paul Cawley1,2, Kuberan Pushparajah3,4, Mary Rutherford1, John Simpson3,4, A. David Edwards1,2, and Serena Counsell1
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Neonatal Intensive Care Unit, Evelina London Children's Hospital, London, United Kingdom, 3Department of Cardiovascular Imaging, School of Biomedical Engineering & Imaging Science, King's College London, London, United Kingdom, 4Department of Congenital Heart Disease, Evelina London Children's Hospital, London, United Kingdom
Reduced cerebral oxygen delivery (CDO2) in infants with congenital heart disease (CHD) is associated with abnormal brain development. We investigated how cerebral blood flow, haemoglobin, and oxygen saturations, which all contribute to CDO2, change following surgery in a cohort of 24 infants with CHD. There was no significant change in CDO2 after surgery (P = 0.62). However, both cerebral blood flow (P < 0.001) and pre-ductal oxygen saturations (P = 0.008) improved significantly, whilst haemoglobin dropped significantly (P < 0.001). Consistent with previous reports, the changes that occur in cerebral blood flow following surgery are dependent on the type of cardiac lesion.
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