Abstract #1238

MRI assessment of cerebral oxygen delivery before and after surgery in infants with congenital heart disease

Daniel Cromb^1,2, Alexandra F Bonthrone¹, Christopher Kelly¹, Paul Cawley^1,2, Kuberan Pushparajah^3,4, Mary Rutherford¹, John Simpson^3,4, A. David Edwards^1,2, and Serena Counsell¹

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Neonatal Intensive Care Unit, Evelina London Children's Hospital, London, United Kingdom, ³Department of Cardiovascular Imaging, School of Biomedical Engineering & Imaging Science, King's College London, London, United Kingdom, ⁴Department of Congenital Heart Disease, Evelina London Children's Hospital, London, United Kingdom

Synopsis

Reduced cerebral oxygen delivery (CDO₂) in infants with congenital heart disease (CHD) is associated with abnormal brain development. We investigated how cerebral blood flow, haemoglobin, and oxygen saturations, which all contribute to CDO₂, change following surgery in a cohort of 24 infants with CHD. There was no significant change in CDO₂ after surgery (P = 0.62). However, both cerebral blood flow (P < 0.001) and pre-ductal oxygen saturations (P = 0.008) improved significantly, whilst haemoglobin dropped significantly (P < 0.001). Consistent with previous reports, the changes that occur in cerebral blood flow following surgery are dependent on the type of cardiac lesion.

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