Common Genetic Variation In IGFBP7 Is Associated With Cortical Brain Development In Preterm Infants
Daniel Cromb1, Harriet Cullen1, Christiaan De Leeuw2, Madeleine Barnett1, Jonathan O'Muircheartaigh1, Serena Counsell1, and A. David Edwards1
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Faculty of Science, Complex Trait Genetics, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
In a cohort of 185 infants born preterm we used linked MR imaging, genomic and neurodevelopmental data, to identify a significant association between common genetic variation in the IGFBP7 gene and cortical grey matter volumes as assessed at term-corrected age (p = 0.0057), as well as motor outcomes as assessed at 18-24 months of age (p = 0.044).
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