Abstract #1241

Common Genetic Variation In IGFBP7 Is Associated With Cortical Brain Development In Preterm Infants

Daniel Cromb¹, Harriet Cullen¹, Christiaan De Leeuw², Madeleine Barnett¹, Jonathan O'Muircheartaigh¹, Serena Counsell¹, and A. David Edwards¹

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Faculty of Science, Complex Trait Genetics, Vrije Universiteit Amsterdam, Amsterdam, Netherlands

Synopsis

In a cohort of 185 infants born preterm we used linked MR imaging, genomic and neurodevelopmental data, to identify a significant association between common genetic variation in the IGFBP7 gene and cortical grey matter volumes as assessed at term-corrected age (p = 0.0057), as well as motor outcomes as assessed at 18-24 months of age (p = 0.044).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.