Abstract #1240
Prenatal and Postnatal Cerebellar Development
Elizabeth Weisse1, Yaqing Chen2, Alvaro Gajardo Cataldo2, Hans-Georg Müller2, Changbo Zhu2, Jonathan O’Muircheartaigh3, Maximilian Pietsch4, Sian Wilson4, Kristofer Bouchard5,6, Sylvia Madhow5,6, James Cole7,8, Francesca Biondo7,9, Viren D’Sa10,11, Sean C. L. Deoni11,12,13, and Muriel M.K. Bruchhage1,11,14
1Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, United States, 2Department of Statistics, UC Davis, Davis, CA, United States, 3Department of Forensic & Neurodevelopmental Sciences, King's College London, London, United Kingdom, 4Centre for the Developing Brain, Department of Perinatal Imaging and Health, King's College London, London, United Kingdom, 5Scientific Data Division & Biological Systems and Engineering Division, LBNL, Berkeley, CA, United States, 6Helen Wills Neuroscience Institute & Redwood Center for Theoretical Neuroscience, UC Berkeley, Berkeley, CA, United States, 7Centre for Medical Image Computing, Computer Science, UCL, London, United Kingdom, 8Dementia Research Centre, Queen Square Institute of Neurology, UCL, London, United Kingdom, 9Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, UCL, London, United Kingdom, 10Department of Pediatrics, Rhode Island Hospital, Providence, RI, United States, 11Department of Pediatrics, Warren Alpert Medical School at Brown University, Providence, RI, United States, 12Brown's Advanced Baby Imaging Lab, Rhode Island Hospital, Providence, RI, United States, 13MRI Research, Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, United States, 14Institute of Social Sciences, Department of Psychology, University of Stavanger, Stavanger, Norway
Synopsis
The cerebellum is one of the earliest structures to develop prenatally and is documented to play an important role in motor development and, more recently, cognitive development. We investigated cerebellar development and its contribution to later overall (ELC), nonverbal (NVDQ) and verbal (VDQ) cognitive development from 22 weeks of gestation to 15 years of age. Total postnatal cerebellar volume significantly increased with ELC and VDQ but decreased with NVDQ, while prenatal cerebellar volume significantly increased with ELC with age. This could be indicative of the cerebellum’s contribution to overall cognitive development refining with development and age.
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