This study reports on the effects of pediatric medulloblastoma therapy in a population of 105 subjects. Longitudinal white matter microstructure was studied starting with the post radiation examination until approximately two years after diagnosis. The tract-based spatial statistics (TBSS) pipeline was used to combine fractional anisotropy (FA) with individual dosimetry maps before linear mixed effects models were calculated for each voxel. Significant voxels were found for increasing FA over time and a decrease of FA over time associated with higher radiation dose. These results are consistent with a recovery in FA that is attenuated by higher doses of radiation.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords