Effect of radiation dose on the recovery of white matter integrity in children treated for medulloblastoma
John O Glass1, Jared J Sullivan1, Yian Guo2, Julie H Harreld1, Yimei Li2, Giles W Robinson3, Amar Gajjar3, Thomas E Merchant4, and Wilburn E Reddick1
1Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States, 2Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, United States, 3Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States, 4Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States
This study reports on the effects of pediatric medulloblastoma therapy in a population of 105 subjects. Longitudinal white matter microstructure was studied starting with the post radiation examination until approximately two years after diagnosis. The tract-based spatial statistics (TBSS) pipeline was used to combine fractional anisotropy (FA) with individual dosimetry maps before linear mixed effects models were calculated for each voxel. Significant voxels were found for increasing FA over time and a decrease of FA over time associated with higher radiation dose. These results are consistent with a recovery in FA that is attenuated by higher doses of radiation.
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