Abstract #1244
Evaluation of quantitative T1 and PD mapping at 7T from an MP2RAGE Sequence optimised to obtain UNI and FLAWS contrast images in a single scan
Ayse Sila Dokumaci1,2, Katy Vecchiato2,3,4, Raphael Tomi-Tricot1,2,5, Pip Bridgen1,2, Michael Eyre1,2, Tobias C. Wood6, Chiara Casella2,4, Jan Sedlacik2,7, Tom Wilkinson1,2, Sharon Giles1,2, Joseph V. Hajnal1,2, Shaihan Malik1,2, Jonathan O’Muircheartaigh2,3,4,8, and David W. Carmichael1,2
1Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2London Collaborative Ultra high field System (LoCUS), London, United Kingdom, 3Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom, 4Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 5MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, 6Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom, 7Radiology Department, Great Ormond Street Hospital for Children, London, United Kingdom, 8MRC Centre for Neurodevelopmental Disorders, King’s College London, London, United Kingdom
Synopsis
The Magnetization Prepared 2 Rapid Acquisition Gradient Echoes (MP2RAGE) sequence is commonly used for 3D structural T1-weighted imaging of the brain at 7T and can be optimised to obtain UNI and clinically relevant FLuid and White Matter Suppression (FLAWS) images within one acquisition. In this study, such a protocol was used together with newly derived analytical equations accounting for partial Fourier acquisitions, and B1+ maps, in a dedicated fitting algorithm to produce quantitative T1 and arbitrarily scaled PD-maps. These maps were evaluated in children and adults at 7T demonstrating a significant T1 reduction with age.
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