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Abstract #1256

T2-dependence of deep and superficial white matter tractography

Yogesh Rathi1, Lipeng Ning1, Congyu Liao2, Yang Ji3, Carl-Fredrik Westin1, Fan Zhang1, Nikolaos Makris1, Lauren J O'Donnell1, and Kawin Setsompop2
1Harvard Medical School, Boston, MA, United States, 2Stanford University, Stanford, CA, United States, 3Oxford University, Oxford, United Kingdom


Tractography is typically obtained from diffusion MRI data acquired at a particular echo time (TE). Recent works have shown differential T2-relaxation times of tissue microstructure and fiber tracts. However, estimation of T2 in fiber bundles have typically been done at the last stage (after tractography). In this work, we show that tractography itself is affected by the T2 (and hence TE) of the fibers. Specifically, we show that the ability to trace accurately depends on the T2 of the fiber bundle. This is specifically true for the superficial white matter (u-fibers) which has higher myelination and iron content.

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