Tractography is typically obtained from diffusion MRI data acquired at a particular echo time (TE). Recent works have shown differential T2-relaxation times of tissue microstructure and fiber tracts. However, estimation of T2 in fiber bundles have typically been done at the last stage (after tractography). In this work, we show that tractography itself is affected by the T2 (and hence TE) of the fibers. Specifically, we show that the ability to trace accurately depends on the T2 of the fiber bundle. This is specifically true for the superficial white matter (u-fibers) which has higher myelination and iron content.
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