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Abstract #1257

Impact of Diffusion Signal Harmonisation on Voxel-Wise Analysis of Mild Traumatic Brain Injury

Stefan Winzeck1,2, Sophie Richter2, Maira Siqueira Pinto3, Evgenios N. Kornaropoulos4, Virginia F.J. Newcombe2, Ben Glocker1, David K. Menon2, and Marta M. Correia5
1BioMedIA, Department of Computing, Imperial College London, London, United Kingdom, 2University Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 3Universitair Ziekenhuis Antwerpen, Antwerp, Belgium, 4Clinical Sciences, Lund, Diagnostic Radiology, Lund University, Lund, Sweden, 5MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom


The comparison of voxel-wise regression analysis of a multi-centre diffusion MRI study showed that similar results could be achieved regardless of whether prior data harmonisation was applied or not. However, harmonisation had a positive impact on increasing the effect size found between mild traumatic brain injury patients and controls.

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