Abstract #1257

Impact of Diffusion Signal Harmonisation on Voxel-Wise Analysis of Mild Traumatic Brain Injury

Stefan Winzeck^1,2, Sophie Richter², Maira Siqueira Pinto³, Evgenios N. Kornaropoulos⁴, Virginia F.J. Newcombe², Ben Glocker¹, David K. Menon², and Marta M. Correia⁵

¹BioMedIA, Department of Computing, Imperial College London, London, United Kingdom, ²University Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ³Universitair Ziekenhuis Antwerpen, Antwerp, Belgium, ⁴Clinical Sciences, Lund, Diagnostic Radiology, Lund University, Lund, Sweden, ⁵MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom

Synopsis

The comparison of voxel-wise regression analysis of a multi-centre diffusion MRI study showed that similar results could be achieved regardless of whether prior data harmonisation was applied or not. However, harmonisation had a positive impact on increasing the effect size found between mild traumatic brain injury patients and controls.

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