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Abstract #1259

Determinants of MR Relaxation in the Extremely Preterm Brain at Adolescence: Myelin and Iron

Ryan McNaughton1,2, Ning Hua2, Lei Zhang3, David Kennedy4, T. Michael O'Shea3, Karl Kuban2, and Hernan Jara2
1Mechanical Engineering, Boston University, Boston, MA, United States, 2Boston University Medical Center, Boston, MA, United States, 3University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 4University of Massachusetts, Worcester, MA, United States


Purpose: To describe the dependencies of multiparametric quantitative MRI (MP-qMRI) on myelin and iron content in the extremely preterm born brain at adolescence. Methods: Algorithms for a fast exchange relaxation (FER) model and MP-qMRI create maps of R1, R2, myelin, and iron in 30 participants using MR images obtained with the triple TSE pulse sequence at age 15 years. Results: R1 and R2 have linear dependencies with myelin and iron content, respectively. Conclusion: Application of a FER model produces coregistered maps of myelin and iron content which exhibit unique influences on the relaxation of white matter and gray matter regions.

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