Abstract #1259

Determinants of MR Relaxation in the Extremely Preterm Brain at Adolescence: Myelin and Iron

Ryan McNaughton^1,2, Ning Hua², Lei Zhang³, David Kennedy⁴, T. Michael O'Shea³, Karl Kuban², and Hernan Jara²

¹Mechanical Engineering, Boston University, Boston, MA, United States, ²Boston University Medical Center, Boston, MA, United States, ³University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁴University of Massachusetts, Worcester, MA, United States

Synopsis

Purpose: To describe the dependencies of multiparametric quantitative MRI (MP-qMRI) on myelin and iron content in the extremely preterm born brain at adolescence. Methods: Algorithms for a fast exchange relaxation (FER) model and MP-qMRI create maps of R1, R2, myelin, and iron in 30 participants using MR images obtained with the triple TSE pulse sequence at age 15 years. Results: R1 and R2 have linear dependencies with myelin and iron content, respectively. Conclusion: Application of a FER model produces coregistered maps of myelin and iron content which exhibit unique influences on the relaxation of white matter and gray matter regions.

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