Abstract #1270

A comprehensive protocol for multiparametric brain MRI

Dvir Radunsky¹, Chen Solomon¹, Tamar Blumenfeld-Katzir¹, Neta Stern¹, Shir Filo², Aviv Mezer², Anita Karsa³, Karin Shmueli³, Lucas Soustelle ⁴, Guillaume Duhamel⁴, Olivier M. Girard⁴, and Noam Ben-Eliezer^1,5,6

¹Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, ²The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel, ³Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ⁴Aix Marseille University, CNRS, CRMBM, Marseille, France, ⁵Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, ⁶Center for Advanced Imaging Innovation and Research (CAI2R), University Langone Medical Center, New York, Israel

Synopsis

The clinical utility of quantitative MRI (qMRI) techniques was demonstrated in numerous pathologies. This work investigated a range of qMRI pulse-sequences and processing methods with proven clinical applicability, aiming to establish a comprehensive and standard qMRI scan protocol for the brain. This multiparametric protocol provides a wide range of numeric maps (e.g., T₁, T₂, T₂*, PD, M₀, B₁⁺, water and macromolecular fractions, susceptibility, mean diffusivity, and more) with whole-brain coverage, diverse set of clinical biomarkers, and the ability for stable longitudinal and multi-center investigations. Limitations and practical tips are provided for users interested in quantitative brain imaging.

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