A comprehensive protocol for multiparametric brain MRI
Dvir Radunsky1, Chen Solomon1, Tamar Blumenfeld-Katzir1, Neta Stern1, Shir Filo2, Aviv Mezer2, Anita Karsa3, Karin Shmueli3, Lucas Soustelle 4, Guillaume Duhamel4, Olivier M. Girard4, and Noam Ben-Eliezer1,5,6
1Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, 2The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel, 3Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 4Aix Marseille University, CNRS, CRMBM, Marseille, France, 5Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, 6Center for Advanced Imaging Innovation and Research (CAI2R), University Langone Medical Center, New York, Israel
The clinical utility of quantitative MRI (qMRI) techniques was demonstrated in numerous pathologies. This work investigated a range of qMRI pulse-sequences and processing methods with proven clinical applicability, aiming to establish a comprehensive and standard qMRI scan protocol for the brain. This multiparametric protocol provides a wide range of numeric maps (e.g., T1, T2, T2*, PD, M0, B1+, water and macromolecular fractions, susceptibility, mean diffusivity, and more) with whole-brain coverage, diverse set of clinical biomarkers, and the ability for stable longitudinal and multi-center investigations. Limitations and practical tips are provided for users interested in quantitative brain imaging.
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