Abstract #1271
Improved spatial normalization of white matter fiber orientation distributions using T1-weighted contrast
Jose M Guerrero-Gonzalez1,2, Olivia Surgent2,3, Nagesh Adluru2,4, Steven R Kecskemeti2, Gregory R Kirk2, Douglas C Dean III1,2,5, Brittany G Travers2,6, and Andrew L Alexander1,2,7
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Waisman Center, University of Wisconsin - Madison, Madison, WI, United States, 3Neuroscience Training Program, University of Wisconsin - Madison, Madison, WI, United States, 4Radiology, University of Wisconsin - Madison, Madison, WI, United States, 5Pediatrics, University of Wisconsin - Madison, Madison, WI, United States, 6Kinesiology Occupational Therapy Program, University of Wisconsin - Madison, Madison, WI, United States, 7Psychiatry, University of Wisconsin - Madison, Madison, WI, United States
Synopsis
Fiber orientation distributions (FOD) derived from diffusion magnetic resonance imaging (dMRI) enable resolution of multiple fiber populations within a voxel. FOD-based white matter studies include voxel-based analysis, atlas-based labeling, and group average fiber tracking. These methods require spatial normalization of the FODs. This work describes an alternative approach for FOD spatial normalization based on co-registering individual dMRI to the T1-weighted (T1w) images, non-linear spatial normalization of the T1w images to a template, and applying the transformations to the FOD maps. This approach is compared to the conventional approach of directly aligning FOD maps.
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