Acquisition of MRI and histology in the same ex-vivo tissue sample enables direct correlation between MR and histologically-derived metrics. Here, we analysed immunohistochemistry images of human visual cortex, anterior cingulate and hippocampus to produce stained area fraction maps for myelin, neurofilaments and microglia. We performed voxelwise correlations between MR parameters (FA, MD, R2*, R1) and histology maps to generally characterise the strength of relationships. We then used partial correlation to identify the unique variance in MR parameters explained by each histological feature, and multiple linear regression to explore how well multiple microstructural properties can together explain MR parameters.
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