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Abstract #1278

Sodium 23Na-MRI relaxometry and tissue sodium content at 15.2T in a murine model of lymphangiogenesis

Shannon L Taylor1,2, Kevin D Harkins2,3, Daniel C Colvin2,3, Joseph M Rutkowski4, Mark D Does1,2,5, John C Gore1,2,3,6,7, and Rachelle L Crescenzi1,2,3
1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 3Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 4Medical Physiology, Texas A&M University College of Medicine, Bryan, TX, United States, 5Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States, 6Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States, 7Physics and Astronomy, Vanderbilt University, Nashville, TN, United States

Synopsis

To investigate questions regarding the physiology of salt storage in skin and muscle and its relationship with lymphangiogenesis, we are developing sodium 23Na-MRI protocols for a mouse model of controllable lymphangiogenesis in adipose tissue. We acquired images at 15.2T from a UTE center-out sequence and quantified sodium longitudinal and bi-exponential transverse relaxation times and tissue sodium content (TSC) in the skin and muscle. Baseline TSC was reduced in animals undergoing lymphangiogenesis compared to littermates, while 23Na-relaxometry was similar. These results will be used for protocol development in this animal model to study sodium and lymphatic physiology.

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