Abstract #1279
Multi-nuclear 1H/23Na Sodium MRI reveals relationship between intermuscular adipose tissue and tissue sodium content
Michael Pridmore1,2, Jorge Gamboa3, Michelle Ormseth3,4, Annette Oeser3, C. Michael Stein3, and Rachelle Crescenzi1,2,5
1Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 3Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States, 4U.S. Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, United States, 5Biomedical Engineering, Vanderbilt University Medical Center, Nashville, TN, United States
Synopsis
Adipose tissue depositions between muscle compartments, known as intermuscular adipose tissue (IMAT), occurs in various conditions such as with obesity and aging. Tissue sodium content (TSC) measured by sodium magnetic resonance imaging increases with aging and may be associated with insulin resistance. In this study, we found a correlation between IMAT volume percentage and muscle TSC (r=0.52, p=0.01). Additionally, mean TSC in the IMAT region was higher than mean TSC in total muscle (p<0.001). The relationship between tissue sodium content and IMAT opens avenues for understanding the mechanisms of sodium storage and fat depositions in tissue compartments of the leg.
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