Abstract #1283

Variability in Brain Sodium Total Sodium Content (TSC) Mapping Quantification Methods

Cameron Nowikow^1,2, Paul Polak^1,2,3, and Michael D Noseworthy^1,2,4

¹School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, ²Imaging Research Centre, St. Joseph's Healthcare, Hamilton, ON, Canada, ³Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, ⁴Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada

Synopsis

Throughout the literature, the methods of quantifying total sodium concentration (TSC) brain maps vary. Some studies use a two calibration phantom approach, some use a one calibration phantom approach, and some use anatomical references to quantify the TSC maps. This abstract investigates the variability of using one method versus another to see if a chosen method will inherently bias the resultant maps. It was found that no bias is provided by one method versus another as they provide no significant variance to the data.

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