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Abstract #1283

Variability in Brain Sodium Total Sodium Content (TSC) Mapping Quantification Methods

Cameron Nowikow1,2, Paul Polak1,2,3, and Michael D Noseworthy1,2,4
1School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, 2Imaging Research Centre, St. Joseph's Healthcare, Hamilton, ON, Canada, 3Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 4Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada


Throughout the literature, the methods of quantifying total sodium concentration (TSC) brain maps vary. Some studies use a two calibration phantom approach, some use a one calibration phantom approach, and some use anatomical references to quantify the TSC maps. This abstract investigates the variability of using one method versus another to see if a chosen method will inherently bias the resultant maps. It was found that no bias is provided by one method versus another as they provide no significant variance to the data.

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