Abstract #1298

Effects of Sleep on perivascular space in healthy population

Nien-Chu Shih¹, Karen Lincoln², Farshid Sepehrband¹, and Jeiran Choupan¹

¹USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, CA, United States

Synopsis

The perivascular space (PVS) has been reported to clear Amyloid-β (Aβ) and metabolic wastes during sleep. However, the relationship between sleep and PVS in a healthy cohort is still unclear. We investigate the association between PVS and sleep across different age groups. We found that the effect of sleep on PVS volume varies in the young and older population.

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