Early post gadolinium T2-W FLAIR signal intensity change in normal brain tissues and CSF: significance for clinical neuroimaging and neurofluids
Nivedita Agarwal1,2,3, Denis Peruzzo1, John Dewitt Port4, Roxana Octavia Carare5, and Graeme Bydder6
1Neuroradiology, I.R.C.C.S. Eugenio Medea, Bosisio Parini, Italy, 2Radiology, Azienda Provinciale per i Servizi Sanitari, Rovereto, Italy, 3Neurosciences, University of Southampton, Southampton, United Kingdom, 4Neuroradiology, Mayo Clinic, Rochester, MN, United States, 5University of Southampton, Southampton, United Kingdom, 6University of San Diego, California, CA, United States
Apart from the study of meningeal diseases, cortical metastases and multiple sclerosis, T2-W FLAIR is used for analyzing the CSF drainage of fluids. However, little is known regarding gadolinium induced signal intensity (SI) changes in the normal gray (GM) and white matter (WM). The SI ratios GM/WM and CSF/WM increase by 2.5% and 7% respectively whereas the SI in WM does not change. These findings are important for the interpretation of clinical findings and will provide better understanding of the movement of neurofluids in the human brain at early time points (e.g.4-5 minutes after GBCA injection).
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