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Abstract #1302

Dynamic BOLD MRI Shows Greater Foot Ischemia and Blunted Reperfusion Following Cuff-Occlusion Challenge in Diabetic Patients with Foot Ulcers

Scott J. Edwards1, Jingting Yao2, Marcos Coutinho Schechter1, Maya Fayfman1, Gabriel Santamarina1, Paula Nesbeth1, Vincent Giacalone1, Gerado Blanco1, Rabindra Tirouvanziam1, Jessica Alvarez1, Benjamin Risk1, Ravi Rajani1, and David A. Reiter1
1Emory University, Atlanta, GA, United States, 2Department of Radiology, Massachusetts General Hospital, Boston, MA, United States


Diabetic foot ulcer (DFU) patients often face incomplete wound healing which leads to a long-term state of inflammation and risk of infection. Prolonged wound healing is thought to result in part from impaired tissue perfusion due to microvascular disease. This study applies dynamic blood-oxygenation-level-dependent (BOLD) imaging to quantify reperfusion of tissue after induced occlusion and ischemia in the foot. When compared to a healthy population, DFU patients show an increased ischemic state during cuff occlusion and decreased reperfusion after release. Quantification of cuff-occlusion parameters may assist in the classification of DFUs and be used to predict the prognosis and enhance treatment plan.

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