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Abstract #1305

Impact of breathing induced off-resonance on labeling efficiency in renal Arterial Spin Labeling

Manuel Taso1 and David C Alsop1
1Division of MRI Research, department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States


Renal Arterial Spin Labeling (ASL) is becoming more widely used as a non-invasive technique for measuring renal perfusion and hence renal function. Free-breathing acquisitions with retrospective motion-correction are commonly used as it facilitates workflow and is robust against uncooperative patients. However, PCASL, especially the balanced implementation in which the same net gradient is used for both label and control, has been shown to be sensitive to off-resonance leading to a loss of labeling efficiency. We propose here a pilot study measuring B0 shifts during free-breathing to simulate its impact on free-breathing renal PCASL perfusion imaging.

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