Abstract #1316
A multi-organ assessment of the acute effects of haemodialysis using intradialytic multiparametric magnetic resonance imaging
Eleanor F Cox1, Venkata Rukmini Latha Gullapudi2,3, Charlotte E Buchanan1, Kelly White3, Sebastian Coleman1, Daniel Cocking1, Isma Kazmi2,3, Katrin Köhler4, Bernard Canaud4, Maarten W Taal2,3, Nicholas M Selby2,3, and Susan T Francis1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Centre for Kidney Research and Innovation, University of Nottingham, Derby, United Kingdom, 3Renal Unit, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, United Kingdom, 4Center of Excellence Medical Europe, Middle East and Africa, Fresenius Medical Care, Bad Homburg, Germany
Synopsis
Twelve patients underwent serial cardiac, cerebral and renal multiparametric 3T MRI scans before, during and after haemodialysis. During dialysis, there was a significant decline in cardiac and stroke index and myocardial strain, with increased diastolic dysfunction. This was accompanied by a reduction in blood flow to both the heart and brain. White matter T1 increased during dialysis suggesting fluid shifts increasing water content resulting in local oedema. Total kidney volume, renal cortex T1 and T2* all reduced during dialysis likely reflecting reduced renal blood volume and change in renal tissue water. These results highlight the acute multi-organ effects of dialysis.
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