ASL inversion efficiency is often assumed as a pre-defined value or estimated by acquiring an additional phase-contrast MR image. While the former approach might be inaccurate in certain conditions, the latter can be time-consuming. Here, we propose a simplified method that estimates blood flow velocity and inversion efficiency solely using the ASL data. This novel strategy was tested using multi-PLD pCASL datasets with two different blood flow dynamics (normo- and hypercapnia). Our results show the feasibility of this approach and highlight the need for subject/condition-specific inversion efficiency estimation for a more accurate quantification of CBF.
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