Abstract #1314

Quantification of regional cerebral blood flow using diffusion imaging with phase-contrast (DIP)

Genki Nambu¹, Naoki Ohno¹, Tosiaki Miyati¹, Fumiki Sugita¹, Yuki Makino², Momoka Ikeda¹, Noam Alperin³, Toshifumi Gabata¹, and Satoshi Kobayashi¹

¹Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan, ²Department of Radiology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan, ³Department of Radiology, University of Miami, Miami, FL, United States

Synopsis

Perfusion-related diffusion coefficient (D^*) in intravoxel incoherent motion analysis is closely correlated with the regional cerebral blood flow (rCBF). However, the D^* is only a semiquantitative relative value of rCBF, which makes absolute rCBF quantification challenging. To solve this problem, we developed a novel method of diffusion imaging with phase contrast (DIP), in which the total CBF (tCBF) from phase-contrast (PC)-MRI was used to convert the perfusion-related parameters in the brain to absolute rCBF. Using this method, we measured rCBF in gray matter and white matter. Each value was consistent with literature values assessed using [¹⁵O]-water positron emission tomography.

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