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Abstract #1314

Quantification of regional cerebral blood flow using diffusion imaging with phase-contrast (DIP)

Genki Nambu1, Naoki Ohno1, Tosiaki Miyati1, Fumiki Sugita1, Yuki Makino2, Momoka Ikeda1, Noam Alperin3, Toshifumi Gabata1, and Satoshi Kobayashi1
1Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan, 2Department of Radiology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan, 3Department of Radiology, University of Miami, Miami, FL, United States


Perfusion-related diffusion coefficient (D*) in intravoxel incoherent motion analysis is closely correlated with the regional cerebral blood flow (rCBF). However, the D* is only a semiquantitative relative value of rCBF, which makes absolute rCBF quantification challenging. To solve this problem, we developed a novel method of diffusion imaging with phase contrast (DIP), in which the total CBF (tCBF) from phase-contrast (PC)-MRI was used to convert the perfusion-related parameters in the brain to absolute rCBF. Using this method, we measured rCBF in gray matter and white matter. Each value was consistent with literature values assessed using [15O]-water positron emission tomography.

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