Specific Quantification of Myelin by QSM and MWI: Comparison to DTI in Mouse of Pelizaeus Merzbacher Disease and Metachromatic Leukodystrophy
Ulrike Loebel1, Lepu Zhou2, Gabriele M Rune2, Michael Sereda3, Theresa Kungel3, Ullrich Matzner4, Jens Fiehler2, Jan Sedlacik1, and Annette Bley2
1Great Ormond Street Hospital for Children, London, United Kingdom, 2University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 3Max-Planck-Institute of Experimental Medicine, Goettingen, Germany, 4Rheinische Friedrich-Wilhelms Universität Bonn, Bonn, Germany
Two different disease models, i.e., of Pelizaeus Merzbacher disease (PMD) and Metachromatic Leukodystrophy (MLD), were studied in mice using QSM, MWF, MTR and DTI as well as histopathology to assess their ability to specifically quantify myelin damage. Electron microscopy of PMD showed damaged myelin, but histological micrographs of MLD showed regular brain tissue integrity but with an abnormal presence of macrophages. Only MWF and QSM showed a difference between PMD and WT, but no difference between MLD and WT, which suggests, that MWF and QSM are highly specific to myelin damage.
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