Two different disease models, i.e., of Pelizaeus Merzbacher disease (PMD) and Metachromatic Leukodystrophy (MLD), were studied in mice using QSM, MWF, MTR and DTI as well as histopathology to assess their ability to specifically quantify myelin damage. Electron microscopy of PMD showed damaged myelin, but histological micrographs of MLD showed regular brain tissue integrity but with an abnormal presence of macrophages. Only MWF and QSM showed a difference between PMD and WT, but no difference between MLD and WT, which suggests, that MWF and QSM are highly specific to myelin damage.
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