Abstract #1323

Specific Quantification of Myelin by QSM and MWI: Comparison to DTI in Mouse of Pelizaeus Merzbacher Disease and Metachromatic Leukodystrophy

Ulrike Loebel¹, Lepu Zhou², Gabriele M Rune², Michael Sereda³, Theresa Kungel³, Ullrich Matzner⁴, Jens Fiehler², Jan Sedlacik¹, and Annette Bley²

¹Great Ormond Street Hospital for Children, London, United Kingdom, ²University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ³Max-Planck-Institute of Experimental Medicine, Goettingen, Germany, ⁴Rheinische Friedrich-Wilhelms Universität Bonn, Bonn, Germany

Synopsis

Two different disease models, i.e., of Pelizaeus Merzbacher disease (PMD) and Metachromatic Leukodystrophy (MLD), were studied in mice using QSM, MWF, MTR and DTI as well as histopathology to assess their ability to specifically quantify myelin damage. Electron microscopy of PMD showed damaged myelin, but histological micrographs of MLD showed regular brain tissue integrity but with an abnormal presence of macrophages. Only MWF and QSM showed a difference between PMD and WT, but no difference between MLD and WT, which suggests, that MWF and QSM are highly specific to myelin damage.

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