Injuries to the developing brain due to hypoxia–ischemia (HI) are common causes of neurological disabilities in preterm babies Lactoferrin (Lf) is an iron-binding protein shown to have antioxidant, anti-inflammatory and anti-apoptotic properties when administered to mothers as a dietary supplement during pregnancy and/or lactation in preclinical studies of developmental brain injuries. Here, we tested three different doses of dietary maternal Lf supplementation using the postnatal day 3 HI model and evaluated the acute neurochemical damage profile using 1H MRS and DTI/NODDI. In conclusion, Lf supplementation attenuates, in a dose-dependent manner, the acute and long-term cerebral injury caused by HI.
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