Abstract #1324

Dose-dependent neuroprotective effects of Bovine Lactoferrin following neonatal hypoxia-ischemia in the immature rat brain

Yohan van de Looij^1,2, Eduardo Sanches¹, Sadou Saw¹, Audrey Toulotte¹, Analina Da Dilva², Laura Modernell¹, and Stéphane V Sizonenko¹

¹Division of Development and Growth, Department of Paediatrics and Gynaecology-Obstetrics, School of Medicine, University of Geneva, Geneva, Switzerland, ²Center for Biomedical Imaging, Animal Imaging Technology section, Federal Institute of Technology of Lausanne, Lausanne, Switzerland

Synopsis

Injuries to the developing brain due to hypoxia–ischemia (HI) are common causes of neurological disabilities in preterm babies Lactoferrin (Lf) is an iron-binding protein shown to have antioxidant, anti-inflammatory and anti-apoptotic properties when administered to mothers as a dietary supplement during pregnancy and/or lactation in preclinical studies of developmental brain injuries. Here, we tested three different doses of dietary maternal Lf supplementation using the postnatal day 3 HI model and evaluated the acute neurochemical damage profile using ¹H MRS and DTI/NODDI. In conclusion, Lf supplementation attenuates, in a dose-dependent manner, the acute and long-term cerebral injury caused by HI.

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