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Abstract #1335

Quantitative analysis of dynamic-contrast enhanced MRI by dispersion analysis for improved prostate cancer diagnosis

Simona Turco1, Catarina Dinis Fernandes2, Razvan Miclea3, Ivo Schoots4, Peet Nooijen5, Hans van der Linden5, Jelle Barentsz6, Stijn Heijmink 7, Hessel Wijkstra2, and Massimo Mischi2
1Electrical Engineering, Eindhoven Univeristy of Technology, Eindhoven, Netherlands, 2Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 3Abdominal radiology, Maastricht University Medical Center, Maastricht, Netherlands, 4Abdominal radiology, Erasmus Medical Center, Rotterdam, Netherlands, 5Uropathology, Jeroen Bosch Ziekenhuis, 's-Hertogenbosch, Netherlands, 6Radiology, Radboud university medical center, Nijmegen, Netherlands, 7Radiology, Netherlands Cancer Institute, Amsterdam, Netherlands


Multiparametric MRI, including T2-weighted, diffusion-weighted, and dynamic contrast enhanced (DCE) imaging, is the recommended imaging modality for prostate cancer (PCa). Although the role of DCE-MRI has been greatly limited in recent years, only qualitative analysis of DCE is currently performed. Here we propose magnetic resonance dispersion imaging (MRDI) to obtain quantitative parametric maps from DCE-MRI. Comparing the performance of two radiologists, our results show that some clinically-significant PCa are only found by interpretation of either mpMRI alone or MRDI maps alone, suggesting that combined interpretation of MRDI and mpMRI may improve PCa diagnosis.

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