Abstract #1336

Comparison of magnetization transfer quantification methods in the sciatic nerve of Charcot-Marie-Tooth Type 1A patients

Alison Roth¹, Yongsheng Chen², Jun Li^2,3, and Richard D. Dortch^1,4,5

¹Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, ²Department of Neurology, Wayne State University, Detroit, MI, United States, ³Department of Neurology, Vanderbilt University, Nashville, TN, United States, ⁴Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ⁵Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Synopsis

Magnetization transfer (MT) can be quantified as the MT ratio (MTR), MT saturation (MTsat), and quantitative MT (qMT) pool-size-ratio (PSR). MTR is a promising peripheral nerve imaging biomarker in inherited neuropathies but has lower pathological specificity compared to MTsat and PSR. Here, MTR and MTsat metrics are compared to PSR. Eighteen subjects received 16 qMT scans, five T₁-weighted scans, and the B₀ and B₁ fields were measured. Mean MTR, MTsat, and PSR were extracted from the sciatic nerve. MTR had the highest SNR (median>15.76) and scan-rescan repeatability (ICC=0.93, CV=4.6%), whereas MTsat had the strongest correlation to PSR (r=0.94, p<0.001).

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