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Abstract #1336

Comparison of magnetization transfer quantification methods in the sciatic nerve of Charcot-Marie-Tooth Type 1A patients

Alison Roth1, Yongsheng Chen2, Jun Li2,3, and Richard D. Dortch1,4,5
1Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Department of Neurology, Wayne State University, Detroit, MI, United States, 3Department of Neurology, Vanderbilt University, Nashville, TN, United States, 4Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 5Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States


Magnetization transfer (MT) can be quantified as the MT ratio (MTR), MT saturation (MTsat), and quantitative MT (qMT) pool-size-ratio (PSR). MTR is a promising peripheral nerve imaging biomarker in inherited neuropathies but has lower pathological specificity compared to MTsat and PSR. Here, MTR and MTsat metrics are compared to PSR. Eighteen subjects received 16 qMT scans, five T1-weighted scans, and the B0 and B1 fields were measured. Mean MTR, MTsat, and PSR were extracted from the sciatic nerve. MTR had the highest SNR (median>15.76) and scan-rescan repeatability (ICC=0.93, CV=4.6%), whereas MTsat had the strongest correlation to PSR (r=0.94, p<0.001).

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