Abstract #1337

Post mortem study of R2* and vessel distance maps across cortical depth

Hendrik Mattern¹, Frank Angenstein², Christian Mawrin³, and Valentina Perosa^2,4,5

¹Biomedical Magnetic Resonance, Otto von Guericke University, Magdeburg, Germany, ²German Center for Neurodegenerative Disease, Magdeburg, Germany, ³Institute of Neuropathology, Medical Faculty at the Otto von Guericke University, Magdeburg, Germany, ⁴J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States, ⁵Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany

Synopsis

In this proof-of-principle study, an image acquisition and processing pipeline was developed to assess the cortical vasculature and its surrounding tissue. To that end, a block of human brain, which included cortex and juxtacortical white matter, was scanned post-mortem at high resolution with a multi-echo GRE sequence at 9.4T. Subsequently, R2* and vessel distance maps (VDM) were computed and their layer-specific patterns analyzed.

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