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Abstract #1337

Post mortem study of R2* and vessel distance maps across cortical depth

Hendrik Mattern1, Frank Angenstein2, Christian Mawrin3, and Valentina Perosa2,4,5
1Biomedical Magnetic Resonance, Otto von Guericke University, Magdeburg, Germany, 2German Center for Neurodegenerative Disease, Magdeburg, Germany, 3Institute of Neuropathology, Medical Faculty at the Otto von Guericke University, Magdeburg, Germany, 4J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States, 5Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany


In this proof-of-principle study, an image acquisition and processing pipeline was developed to assess the cortical vasculature and its surrounding tissue. To that end, a block of human brain, which included cortex and juxtacortical white matter, was scanned post-mortem at high resolution with a multi-echo GRE sequence at 9.4T. Subsequently, R2* and vessel distance maps (VDM) were computed and their layer-specific patterns analyzed.

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