Free-Breathing R2* Mapping for Hepatic Iron Quantification Using Respiratory Motion-Resolved 3D Multi-Echo UTE Cones MRI
MungSoo Kang1,2, Yan Wen3, Michael Carl3, Gerald G. Behr4, Ricardo Otazo1,4, and Youngwook Kee1
1Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, 3GE Healthcare, Waukesha, WI, United States, 4Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States
Respiratory motion is one of the major factors hindering accurate R2* mapping for hepatic iron quantification. In this work, motion-resolved 3D multi-echo UTE cones MRI with pseudo-random view ordering was implemented for motion-robust and free-breathing R2* mapping of hepatic iron. Compared to conventional gridding reconstruction, motion-resolved reconstruction reduced the overestimation of R2* induced by respiratory motion artifacts, enabling an accurate measurement of R2*. 3D multi-echo UTE cones MRI with motion-resolved reconstruction demonstrated the feasibility of accurate free-breathing R2* mapping for hepatic iron quantification.
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