Abstract #1351
Double Quantum Filtered 2H Measurements in Human Subjects Following Deuterium Oxide Loading
Robin Damion1,2,3, Daniel Cocking3,4, Hester Franks1, Daniel Wilkinson5,6, Matthew Brook2,6,7, Dorothee Auer1,2,3, and Richard Bowtell2,3,4
1School of Medicine, University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Biomedical Research Centre/Nottingham Clinical Research Facilities, University of Nottingham, Nottingham, United Kingdom, 3Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 4School of Physics & Astronomy, University of Nottingham, Nottingham, United Kingdom, 5Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Nottingham, United Kingdom, 6MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Nottingham, Nottingham, United Kingdom, 7School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
Synopsis
Double-quantum filtered (DQF) deuterium spectra were obtained on a 3T scanner from lower leg and forearm muscles of volunteers whose deuterium abundance was increased by approximately 100 times through ingestion of deuterium oxide. Quadrupolar splitting frequencies of approximately 20 – 40 Hz were measured throughout the various muscle groups of the lower leg, with some regions showing little or no splitting. Although the DQF sequence considerably reduces the signal intensity, it has the advantage that it removes any isotropic signal component and therefore reveals an anisotropic component that might have been obscured.
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