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Abstract #1352

Deuterium Metabolic Imaging for 3D Mapping of Human Brain Metabolism at 3T

Philip M. Adamson1, Keshav Datta2, Ron Watkins2, Lawrence Recht3, Ralph Hurd2, and Daniel Spielman2
1Department of Electrical Engineering, Stanford University, Palo Alto, CA, United States, 2Department of Radiology, Stanford University, Palo Alto, CA, United States, 3Department of Neurology, Stanford University, Palo Alto, CA, United States


Deuterium metabolic imaging (DMI) is an emerging modality for investigating glucose metabolism with particular application for assessing the Warburg effect in tumors. Although high field systems, e.g., 7T, provide maximal signal-to-noise ratio (SNR), implementation on widely available 3T scanners could have immediate clinical impact. Using a birdcage 2H RF coil, modified gradient filter, and spherical k-space sampling, we demonstrate high-quality 3T whole-brain DMI of healthy adults following the oral ingestion of deuterated glucose. Results from these experiments provide critical data needed to explore DMI SNR, spatial resolution, and imaging time tradeoffs.

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