Abstract #1352

Deuterium Metabolic Imaging for 3D Mapping of Human Brain Metabolism at 3T

Philip M. Adamson¹, Keshav Datta², Ron Watkins², Lawrence Recht³, Ralph Hurd², and Daniel Spielman²

¹Department of Electrical Engineering, Stanford University, Palo Alto, CA, United States, ²Department of Radiology, Stanford University, Palo Alto, CA, United States, ³Department of Neurology, Stanford University, Palo Alto, CA, United States

Synopsis

Deuterium metabolic imaging (DMI) is an emerging modality for investigating glucose metabolism with particular application for assessing the Warburg effect in tumors. Although high field systems, e.g., 7T, provide maximal signal-to-noise ratio (SNR), implementation on widely available 3T scanners could have immediate clinical impact. Using a birdcage ²H RF coil, modified gradient filter, and spherical k-space sampling, we demonstrate high-quality 3T whole-brain DMI of healthy adults following the oral ingestion of deuterated glucose. Results from these experiments provide critical data needed to explore DMI SNR, spatial resolution, and imaging time tradeoffs.

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